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Yin Wang Selected Research

Echinomycin

1/2022Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues.
1/2022Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes.
9/2021The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin.
2/2021Dual Targeting Oncoproteins MYC and HIF1α Regresses Tumor Growth of Lung Cancer and Lymphoma.
1/2021Targeting the HIF-1α-IGFBP2 axis therapeutically reduces IGF1-AKT signaling and blocks the growth and metastasis of relapsed anaplastic Wilms tumor.
10/2020Liposomal formulation of HIF-1α inhibitor echinomycin eliminates established metastases of triple-negative breast cancer.
1/2020Therapeutic targeting of TP53-mutated acute myeloid leukemia by inhibiting HIF-1α with echinomycin.
8/2014Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells.
4/2011Targeting HIF1α eliminates cancer stem cells in hematological malignancies.

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Yin Wang Research Topics

Disease

134Neoplasms (Cancer)
11/2022 - 05/2006
25Infections
01/2022 - 04/2010
20Inflammation (Inflammations)
06/2022 - 01/2003
18Glioma (Gliomas)
12/2021 - 07/2009
13Pain (Aches)
01/2022 - 04/2009
10Carcinogenesis
03/2022 - 09/2012
9Necrosis
08/2022 - 04/2013
9Fibrosis (Cirrhosis)
06/2022 - 05/2008
9Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 09/2007
9Hypoxia (Hypoxemia)
01/2022 - 05/2012
8Diabetic Nephropathies (Diabetic Nephropathy)
06/2022 - 09/2003
8Atherosclerosis
01/2022 - 03/2005
8Urinary Bladder Neoplasms (Bladder Cancer)
01/2020 - 07/2014
8Osteoporosis
01/2017 - 09/2007
7Neoplasm Metastasis (Metastasis)
02/2022 - 05/2004
7Cardiotoxicity
09/2021 - 04/2015
7Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2021 - 09/2012
7Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021 - 10/2003
6Hemorrhage
10/2022 - 07/2005
6Body Weight (Weight, Body)
06/2022 - 06/2006
6Virus Diseases (Viral Diseases)
01/2022 - 01/2019
6Glioblastoma (Glioblastoma Multiforme)
10/2021 - 12/2010
6Lymphoma (Lymphomas)
02/2021 - 06/2008
6Reperfusion Injury
12/2019 - 03/2005
6Enteritis
01/2014 - 06/2010
5Alzheimer Disease (Alzheimer's Disease)
08/2022 - 10/2018
5Hepatocellular Carcinoma (Hepatoma)
06/2022 - 01/2018
5Pancreatic Neoplasms (Pancreatic Cancer)
06/2022 - 01/2014
5Heart Failure
04/2022 - 12/2015
5Human Influenza (Influenza)
03/2022 - 01/2016
5Pathologic Processes
03/2022 - 11/2019
5Leukemia
01/2022 - 08/2014
5Myocardial Ischemia (Ischemic Heart Diseases)
01/2022 - 03/2005
5Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2020 - 01/2015
5Stroke (Strokes)
10/2020 - 08/2006
5Meningioma (Meningiomas)
01/2019 - 06/2014
5Carcinoma (Carcinomatosis)
08/2018 - 09/2002
5Astrocytoma (Pilocytic Astrocytoma)
01/2018 - 07/2009
4Adenocarcinoma of Lung
11/2022 - 10/2020
4COVID-19
09/2022 - 01/2020
4Pneumonia (Pneumonitis)
04/2022 - 01/2020
4Breast Neoplasms (Breast Cancer)
04/2022 - 07/2009
4Infarction (Infarctions)
01/2022 - 12/2015
4Neuralgia (Stump Neuralgia)
12/2021 - 08/2014
4Cardiomegaly (Heart Hypertrophy)
09/2021 - 04/2014
4Brain Neoplasms (Brain Tumor)
09/2021 - 08/2013
4Sepsis (Septicemia)
01/2021 - 05/2014
4Muscular Diseases (Myopathy)
11/2018 - 03/2011
4Asthma (Bronchial Asthma)
09/2018 - 01/2012
4Oligodendroglioma
01/2018 - 07/2009
4Bone Resorption
11/2015 - 06/2006

Drug/Important Bio-Agent (IBA)

62Proteins (Proteins, Gene)FDA Link
10/2022 - 09/2003
27Biomarkers (Surrogate Marker)IBA
11/2022 - 12/2012
25Pharmaceutical PreparationsIBA
01/2022 - 01/2011
24MicroRNAs (MicroRNA)IBA
06/2022 - 04/2011
14CytokinesIBA
06/2022 - 04/2010
13Therapeutic UsesIBA
07/2022 - 04/2006
13Messenger RNA (mRNA)IBA
01/2022 - 03/2002
11Biological ProductsIBA
03/2022 - 04/2012
11DNA (Deoxyribonucleic Acid)IBA
01/2021 - 09/2012
10Doxorubicin (Adriamycin)FDA LinkGeneric
09/2021 - 04/2015
9Long Noncoding RNAIBA
06/2022 - 04/2014
9EchinomycinIBA
01/2022 - 04/2011
9MicellesIBA
01/2022 - 08/2013
9RNA (Ribonucleic Acid)IBA
01/2022 - 01/2014
8AntioxidantsIBA
06/2022 - 05/2012
8Small Interfering RNA (siRNA)IBA
01/2021 - 07/2009
8ProdrugsIBA
01/2019 - 08/2013
7Circular RNAIBA
06/2022 - 01/2020
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2022 - 01/2003
6Glucose (Dextrose)FDA LinkGeneric
06/2022 - 03/2008
6AntibodiesIBA
01/2022 - 04/2010
6Phosphotransferases (Kinase)IBA
01/2021 - 06/2008
6GlycogenIBA
10/2015 - 07/2012
5Reactive Oxygen Species (Oxygen Radicals)IBA
07/2022 - 05/2012
5Interleukin-6 (Interleukin 6)IBA
06/2022 - 01/2016
5LipopolysaccharidesIBA
01/2022 - 04/2011
5VaccinesIBA
05/2021 - 02/2013
5Caspase 3 (Caspase-3)IBA
03/2021 - 01/2008
5Antiviral Agents (Antivirals)IBA
01/2021 - 05/2013
5EnzymesIBA
12/2020 - 05/2004
5ParaffinIBA
01/2018 - 07/2009
4ChromatinIBA
08/2022 - 12/2014
4CollagenIBA
06/2022 - 03/2008
4Anti-Bacterial Agents (Antibiotics)IBA
01/2022 - 01/2019
4Folic Acid (Vitamin M)FDA LinkGeneric
01/2022 - 01/2011
4Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
09/2021 - 09/2012
4Immunoglobulin E (IgE)IBA
04/2021 - 01/2016
4Mucin-1 (CA 15-3 Antigen)IBA
01/2021 - 09/2010
4Immunoglobulin G (IgG)IBA
01/2021 - 04/2010
4Influenza Vaccines (Influenza Vaccine)FDA Link
12/2020 - 01/2016
4Cisplatin (Platino)FDA LinkGeneric
01/2018 - 11/2010

Therapy/Procedure

65Therapeutics
11/2022 - 01/2003
15Drug Therapy (Chemotherapy)
09/2022 - 01/2011
8Radiotherapy
01/2022 - 09/2002
5Punctures
05/2022 - 10/2008
4Precision Medicine
02/2022 - 01/2016
4Immunotherapy
01/2022 - 01/2016
4Ligation
01/2022 - 05/2012
4Chinese Traditional Medicine (Traditional Chinese Medicine)
06/2016 - 01/2011